解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue. In the present study, canine coronary arterial rings were incubated with various treatments and exposed to 5HT (4 X 10(-7) M) and anoxia (95% N2 and 5% CO2). Developed tension was increased by 250 +/- ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138211
更新日期:1986-01-01 00:00:00
abstract::The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138176
更新日期:1986-01-01 00:00:00
abstract::The regulatory action exerted on receptors by acebutolol, a cardioselective beta-blocker containing intrinsic sympathomimetic activity, has been investigated. beta-Adrenoceptor affinity and density of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 400 mg/day acebutol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138132
更新日期:1985-01-01 00:00:00
abstract::The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138049
更新日期:1985-01-01 00:00:00
abstract::Hamster renal cytosol binds [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with high specificity. Sucrose density gradient centrifugation revealed two binding entities- one with a low sedimentation coefficient of 4-5 S which was displaced by neither TCDD nor other polycyclic aromatic hydrocarbons (PAHs) and another w...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138074
更新日期:1985-01-01 00:00:00
abstract::The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10(-6) M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by si...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138088
更新日期:1985-01-01 00:00:00
abstract::Increased concentrations of immunoreactive methionine-enkephalin but not leucine-enkephalin were measured in fractions of cerebrospinal fluid perfusate collected from ventricular-cisternally perfused, urethane-anesthetized rats exposed to a mixture of 75% nitrous oxide/25% oxygen for 60 min. These findings suggest tha...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138056
更新日期:1985-01-01 00:00:00
abstract::The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138107
更新日期:1985-01-01 00:00:00
abstract::The distribution pattern of (-)-3H-dihydroalprenolol (3H-DHA) binding sites within the thoracic and abdominal aorta was studied using a histoautoradiographic technique. Frozen sections of rabbit aorta were incubated with 3H-DHA in the presence or absence of 1 mumol/l (-)-propranolol and of increasing concentrations of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138065
更新日期:1985-01-01 00:00:00
abstract::It has previously been demonstrated in several species that the secretory granules of pancreatic beta-cells have the ability to store substantial amounts of calcium and bioactive amines, such as dopamine and serotonin. Furthermore, evidence for a similar topographical localization for amine and calcium within the peri...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138053
更新日期:1985-01-01 00:00:00
abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138136
更新日期:1985-01-01 00:00:00
abstract::Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138130
更新日期:1985-01-01 00:00:00
abstract::Cathinone, the active principle of Catha edulis (khat), shows long-lasting analgesic effects when the tail-flick test is used in rats. The involvement of monoamines, endogenous opioids and stress in this analgesic effect was tested. Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138023
更新日期:1984-01-01 00:00:00
abstract::Various attempts to developing antagonists for substance P (SP) and related peptides, based on our past experience with angiotensin, kinins, and neurotensin, were unsuccessful. The particular features of SP, namely the high activity of C-terminal partial sequences in some pharmacological tests were used to develop one...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000137979
更新日期:1984-01-01 00:00:00
abstract::Feeding a thiamin-deficient diet to male and female rats for 3 weeks alters the mixed function oxidases responsible for metabolizing benzo(a)pyrene and enhances the response of these enzymes to induction by phenobarbital or 3-methylcholanthrene. The caloric restriction observed in thiamin deprivation may be partially ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138004
更新日期:1984-01-01 00:00:00
abstract::Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137991
更新日期:1984-01-01 00:00:00
abstract::The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137973
更新日期:1984-01-01 00:00:00
abstract::The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137947
更新日期:1984-01-01 00:00:00
abstract::The effects of alpha-adrenergic agonists on 45Ca efflux from slices of rat liver were studied and the results compared to earlier studies on the rabbit aorta. Norepinephrine and phenylephrine (PE) cause a stimulation of 45Ca efflux which was due to alpha 1-receptor activation. The mitochondrial uncoupler dinitrophenol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137952
更新日期:1984-01-01 00:00:00
abstract::In a randomized three-phase crossover study, 12 healthy male volunteers were given three 12-hourly 500-mg doses of erythromycin base, as enteric coated pellets in capsules (2 X 250 mg), erythromycin stearate tablet (1 X 500 mg), or erythromycin ethylsuccinate sachet (1 X 500 mg). The reaction time after administration...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000138029
更新日期:1984-01-01 00:00:00
abstract::A rapid and sensitive gas chromatographic method for the determination of the beta-adrenergic agent isoxsuprine in human plasma has been developed. The procedure involves the extraction of the drug with ether and an internal standard (propranolol) from plasma at alkaline pH, solvent evaporation, and the formation of a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137843
更新日期:1983-01-01 00:00:00
abstract::A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase. Phenylbutazone, aminopyrine, 1,3-diphenylisobenzofuran, paracetamol, p-aminophenol, p-phenetidine and other o- and m-substituted aminop...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137880
更新日期:1983-01-01 00:00:00
abstract::Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137813
更新日期:1983-01-01 00:00:00
abstract::The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean fecal blood loss of 4.2 ml/day, compared with subject...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137895
更新日期:1983-01-01 00:00:00
abstract::A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137885
更新日期:1983-01-01 00:00:00
abstract::A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significant...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137927
更新日期:1983-01-01 00:00:00
abstract::A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137923
更新日期:1983-01-01 00:00:00
abstract::Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting to study the interaction of ZPC with rat brain receptors and spe...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137912
更新日期:1983-01-01 00:00:00
abstract::In the present paper, two experiments are performed to test the efficacy of the intravenous administration of hypertonic glucose (25 or 50%) in alcoholic intoxication. In a first experiment, 10 healthy, nonstarved volunteers, received 15 min after the ingestion of 1.0 g/kg alcohol, 40 ml of 25% glucose i.v., the same ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137769
更新日期:1983-01-01 00:00:00
abstract::Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137786
更新日期:1983-01-01 00:00:00
abstract::43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days. Both drugs produced an improvement in subjective symptoms by day 7, although the most rapid analgesic effect was obtained with suprofen. Patients receiving suprofen experienced a signi...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137898
更新日期:1983-01-01 00:00:00
abstract::In gross behavioral observation the minimum effective dose of zopiclone was intravenously 0.06-0.25 mg/kg and intragastrically 1-4 mg/kg in rhesus monkeys. Zopiclone suppressed barbital withdrawal signs of rhesus monkeys at a single dose of 16 mg/kg or more. The suppressing effect of zopiclone 32 mg/kg i.g. was compar...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137930
更新日期:1983-01-01 00:00:00
abstract::Three doses (0.31, 3.1 and 31 mg/kg) of methotrexate (MTX) were given intravenously to rats. The resulting concentration-time curves in plasma (normalized by dividing the plasma concentration by a multiple of the dose) were not superimposable, indicating nonlinear plasma pharmacokinetics. In liver, kidney, bone marrow...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137723
更新日期:1982-01-01 00:00:00
abstract::The antinociceptive effect in mice (hot-plate test) of caerulein (0.15 mg/kg s.c.) was many times more resistant to naloxone than that of morphine (2 mg/kg s.c., equipotent with the caerulein dose). The ED50 (mg/kg s.c.) of naloxone (given simultaneously with an agonist) was with morphine 0.01 and with caerulein 0.07....
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137733
更新日期:1982-01-01 00:00:00
abstract::Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have less than 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137732
更新日期:1982-01-01 00:00:00
abstract::Three carcinogens with different requirements for activation were used to generate sister chromatid exchange (SCE) in cultured lymphocytes from 22 untreated patients with solid tumors. These data were compared to SCEs produced by incubating lymphocytes, from 44 normal persons, with the same carcinogens. In vitro treat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137578
更新日期:1982-01-01 00:00:00
abstract::Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137758
更新日期:1982-01-01 00:00:00
abstract::A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the prep...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137598
更新日期:1982-01-01 00:00:00
abstract::Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure liquid chromatographic assay method. Comparison with newly synthesized,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137594
更新日期:1982-01-01 00:00:00
abstract::The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137488
更新日期:1981-01-01 00:00:00